MODELS & EXPERTISE

Validated In Vivo Models for Translational
Decision-Making

Faster start-up • Scientific coordination • European model access

InVivoBridge provides access to preclinical in vivo models through a

coordinated network of certified CRO and academic partners across Germany

and the Netherlands.


Our infection and immunology-focused portfolio supports vaccine, biologic,

antibody, and immunotherapy development ensuring data reliability and

regulatory compliance.

What We Offer

We connect biotech innovators with validated infection and immunology

models that accelerate preclinical decisions.

 Each model is backed by certified partners and managed through

coordinated scientific oversight ensuring consistency and reproducibility

across studies.

Flexible Collaboration
Options

 Every biotech program is unique. InVivoBridge offers flexible engagement

formats tailored to your study needs.

PK/PD & Safety
Models

Dose optimization, tolerability, exposure analysis.

Infection Challenge
Models

Realistic bacterial and viral infection simulations.

Efficacy & Immunogenicity
Models

Vaccine and therapeutic performance assessment.

Biodistribution
Tracking

In vivo fluorescence / bioluminescence imaging.

Proof-of-Concept
Models

Early-stage data for rapid go/no-go decisions.

Pathogen
Portfolio

Bacterial Models:

 
  • Streptococcus pneumoniae
  • Bordetella pertussis
  • Haemophilus influenzae
  • Staphylococcus aureus 

Viral Models:

 
  • Influenza A (H1N1/H3N2)
  • Respiratory Syncytial Virus (RSV)
  • SARS-CoV-2 (BSL-3 access)

Emerging Targets:

 
  • Mycobacterium tuberculosis 
  • Co-infection and mucosal immunity projects

Study Endpoints

1. Pathogen load (CFU / TCID50)


2. Survival and disease scoring


3. Lung pathology / histology


4. Flow cytometry immune profiling


5. Cytokine analysis


6. Antibody titres / neutralization

Regulatory & Ethical
Compliance

All studies coordinated through InVivoBridge adhere strictly to international

ethical and regulatory standards, ensuring animal welfare and scientific

integrity.

EU Directive 2010/63
Paragraph 44 (Germany – IfSG)
Article 9 (Netherlands – Dierproevenwet)
FELASA B Animal Handling Certification

Ready to Move Your Preclinical Studies Forward?

Let’s align science, strategy, and execution to accelerate your next in vivo program efficiently and compliantly across Europe.